The Pfizer and AstraZeneca vaccines are more than 80% effective at preventing COVID-19 hospitalizations in people over age 80 after one dose, Public Health England said on Monday, citing a study released on medRxiv ahead of peer review.
The UK study also found that in people over age 70, two doses of the Pfizer vaccine are approximately 85% to 90% effective at preventing symptomatic disease.
Pfizer vaccine recipients in that age group who did acquire symptomatic infections had a 44% lower risk of hospitalization and a 51% lower risk of death compared
to unvaccinated patients. Because the two-dose AstraZeneca vaccine had only recently been introduced, researchers only had data after one dose. The effect against symptomatic disease was approximately 60% to 75%, and there was also a protective effect against hospitalization, the researchers said.They noted that the AstraZeneca data was gathered while a more-infectious variant was predominant in the UK. Britain’s use of the AstraZeneca vaccine on elderly people contrasts with many European countries, which have cited a lack of clinical trial data for their decision not to use it on older people.
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